Roles of Hepatic Innate and Innate-Like Lymphocytes in Nonalcoholic Steatohepatitis
نویسندگان
چکیده
منابع مشابه
Corrigendum: Ontogeny of Innate T Lymphocytes – Some Innate Lymphocytes Are More Innate Than Others
[This corrects the article on p. 486 in vol. 5, PMID: 25346734.].
متن کاملOntogeny of Innate T Lymphocytes – Some Innate Lymphocytes are More Innate than Others
Innate lymphocytes have recently received a lot of attention. However, there are different ideas about the definition of what is "innate" in lymphocytes. Lymphocytes without V(D)J-rearranged antigen receptors are now termed innate lymphoid cells (ILCs) and include cells formerly known as natural killer (NK) cells. Also, lymphocytes that are innate should be able to recognize microbial or stress...
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Non-alcoholic fatty liver disease represents a growing clinical problem worldwide [1,2]. Recent studies in a European population demonstrated NAFLD in 94% of patients with a BMI exceeding 30 kg/m2 and perhaps more troubling in 25% of patients with a normal BMI (<25). Clear complications are associated with excess hepatic lipid accumulation from stimulation of marked inflammation to more severe ...
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Nonalcoholic steatohepatitis (NASH) is an inflammatory lipotoxic disorder, but how inflammatory cells are recruited and activated within the liver is still unclear. We previously reported that lipotoxic hepatocytes release CXCL10-enriched extracellular vesicles, which are potently chemotactic for cells of the innate immune system. In the present study, we sought to determine the innate immune c...
متن کاملKiller Cell Immunoglobulin-Like Receptors Influence the Innate and Adaptive Immune Responses
Natural killer (NK) cells are a subset of lymphocytes which play a crucial role in early innate immune response against infection and tumor transformation. Furthermore, they secrete interferon-γ (IFN-γ) and tumor necrosis factor (TNF) prompting adaptive immu-nity. NK cells distinguish the unhealthy cells from the healthy ones through an array of cell-surface receptors. Human NK cells use inhibi...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2020
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.01500